Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom
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چکیده
منابع مشابه
Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom
Scorpions are among the oldest venomous living organisms and the family Buthidae is the largest and most medically relevant one. Scorpion venoms include many toxic peptides, but recently, a metalloprotease from Tityus serrulatus called antarease was reported to be capable of cleaving VAMP2, a protein involved in the neuroparalytic syndromes of tetanus and botulism. We have produced antarease an...
متن کاملElectrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure
In Brazil, Tityus serrulatus (Ts) is the species responsible for most of the scorpion related accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx) present high interest, due to their effect in the envenoming process and the ion channel specificity they display. The α-KTx toxins family is the most relevant because its toxins can be used as therapeutic tools f...
متن کاملAge effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats.
The pharmacokinetics of scorpion venom and its toxins has been investigated in experimental models using adult animals, although, severe scorpion accidents are associated more frequently with children. We compared the effect of age on the pharmacokinetics of tityustoxin, one of the most active principles of Tityus serrulatus venom, in young male/female rats (21-22 days old, N=5-8) and in adult ...
متن کاملToxicity of crude and detoxified Tityus serrulatus venom in anti-venom-producing sheep
Specific anti-venom used to treat scorpion envenomation is usually obtained from horses after hyperimmunization with crude scorpion venom. However, immunized animals often become ill because of the toxic effects of the immunogens used. This study was conducted to evaluate the toxic and immunogenic activities of crude and detoxified Tityus serrulatus (Ts) venom in sheep during the production of ...
متن کاملProteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions
BACKGROUND Except for the northern region, where the Amazonian black scorpion, T. obscurus, represents the predominant and most medically relevant scorpion species, Tityus serrulatus, the Brazilian yellow scorpion, is widely distributed throughout Brazil, causing most envenoming and fatalities due to scorpion sting. In order to evaluate and compare the diversity of venom components of Tityus ob...
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ژورنال
عنوان ژورنال: Toxins
سال: 2017
ISSN: 2072-6651
DOI: 10.3390/toxins9030081